THE INFLUENCE OF CIMETIDINE ON THE PHARMACOKINETICS OF FTORAFUR IN RATS / 中国药理学通报

ABSTRACT

The influence of cimetidine on the pharmacokinetics of ftorafur ( FT-207 ) in 9 rats after intragastric administration were investigated with cross-over design. The concentration of ftorafur in serum was determined by reversed-phase HPLC. Its curve of concentration vs time was fit to one compartment opened model. The serum concentrations and areas under the curve ( AUC ) vs time were increased when cimetidine orally administered daily for 5d or single dose. The peak of serum and AUC of ftorafur were increased by 21 .0%(P