ANTI-ANOXIC EFFECTS OF BERBER1NE IN INTACT MICE / 中国药理学通报

ABSTRACT

Berberine sulfate ( Ber ) sc prolonged the survival time of mice under the condition of closed normobaric hypoxia, but Ber ig did not. Ber sc antagonized the effects of decreasing the survival time of mice by ip isoprenaline or phentolamine under the condition of closed normobaric hypoxia, prolonged decapitation-induced gasping duration in mice, and prolonged the survival time in mice poisoned by KCN, NaNO2 or lidocaine. Ber ig prolonged decapitation-induced gasping duration and the survival time in mice poisoned by lidocaine, too. But the effects of Ber ig were not so potent as Ber sc. The antianoxic effects of Ber was shown to be decreasing O2 consumption of body and raising the ability of body to utilize O2 under the condition of hypoxia.