THE EFFECTS OF ?-ELEMENE ON DNA-BINDING SPECIFICITY AND RNA POLYMERASE INHIBITORY ACTIVITY / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Artigo
em Chinês
| WPRIM
| ID: wpr-550482
ABSTRACT
?-elemene that is an element of the Essential oil of the Cuicu-ma Wenyujin showed appreciable anticancer ability. The experimental results showed that the RNA polymerase activity was inhibited by ?-elemene at concentrations of 0.0074 mol/L~0.0172 mol/L. The study of thermal denaturation indicated that the Tm of DNA was decreased after adding ?-elemene. The fluorescent analysis of ?-elemene bound to DNA showed that the intensity of fluorescence was increased. The peak of absorption of DNA was shifted from 260 nm to 240 nm after treatment with ?-elemene.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Artigo
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