STUDY ON PHARMACOKINETICS OF PROBIMANE FOR ORAL ADMINISTRATION IN RABBIT / 中国药理学通报

ABSTRACT

Pharmaco kinetics of probimane in rabbits was studied by using high-performance liguid chromatography. After the oral adiminis-tration of probimane 75mg/kg to rabbits,the phatmacokinetic characteristics are found to fit a two compartment open model. The pharmacokinetic parameters are tl/2? = 0.1933h, tl/2? = 4.9568h, K21 =2.9410h-1, K10=0.6492h-1 K12=3.75l2h-1 AUC = 98.9l01h ? mg/L, Cls=0.7583L? kg-1 ? h-1, V/f(c) = 1.0924L ? kg-1, VSS=1.5114L. kg-1.