EFFECTS OF MELATONIN AND SUPERNATANTS FROM CULTURED RATS PINEAL GLAND ON INTERLEUKIN 1 PRODUCTION / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
em Zh
| WPRIM
| ID: wpr-550689
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WPRO
ABSTRACT
Effects of melatonin ( MT ) and supernatants from cultured pineal glands stimulated by 10 ?mol/L isoproterenol (ISO) for 0, 30, 60, 120 min on interleukin I ( IL-1 ) production by peritoneal macrophage ( PM? ) in rats were studied. Theses results showed that LPS-induced IL-1 production by PM? was enhanced by in vitro treatment with MT (0.1~1 ?mol/L ) , but IL-1 production was not influenced by MT without LPS. LPS-induced IL-1 production by PM? was enhanced in various degree by the supernatants, action of supernatants for 60min was best. The data is suggested that LPS-activated M?s may be one of target cells for MT.
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Article