Defibrase shows no direct thrombolytic actions / 中国药理学通报

ABSTRACT

In the in vitro model of thrombolysis designed by ourselves, urokinase (500 000~ 5 000 000IU ? L-1) reduced the weight of artificial thrombi in a way of dose-dependence. At the level of 2 000 000 IU ? L-1, the action reached the peak. On the contrary, defibrase (6. 25~25 IU ? L-1) dose-relatedly increased the thrombus weight. After defibrinogenation in platelet-poor plasma by addition of porcine thrombin (100 000 IU ? L-1) , defibrase no longer increased the thrombus weight, whereas in comparison with saline, defibrase still showed no apprciable reduction in thrombus weight. The findings hinted that defibrase may have no direct thrombolytic property.