Effects of artesunate on the hepatic GSH content in normal and hepatotoxin-poisoned mice / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Artigo
em Chinês
| WPRIM
| ID: wpr-551032
ABSTRACT
This study was undertaken to examine the possible effects of Artesunate(Art) on the hepatic reduced glutathione(GSH) content in normal and hepatotoxin - poisoned mice. It was demonstrated that Art given ip( 100mg?kg-1or 200mg?kg-1 ? 3)to mice had a signifcant protection against hepatic GSH deplection induced by acetaminophen and yellow phosphorus, andthat Art also caused a marked increase of the hepatic GSH content in fasting mice at the dose of 200mg ? kg-1. These results indicate that Art can help the liver detoxication of toxic metabolits in mice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Artigo
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