Immunopharmacologic effects of Epimedium Polysaccharide and Icarrin on mouse thymus / 中国药理学通报

ABSTRACT

In this paper we report im-munopharmacologic effects of Epimedium Polysaccharide (EPS) and Icarrin on mouse thy-mus. It was found that EPS or Icarrin administered subcutaneously in mouse had following effects (1)EPS enhanced the proliferation and IL-2 production of thymocytes, and decreased the L3T4 and Lyt2 cell numbers and responses to Con A stimulation of the thymus; (2) Icarrinincreased response to ConA stimulation to mouse thymus cell. These results suggest that both EPS and Icarrin have immunes stimulating effect on thymus. EPS possibly promoted the migration of thymocytes from the thymus to peripheral organs.