Experimental study of treating corneal alkali burns with ?_2-macroglobulin / 眼科

ABSTRACT

The study aimed to search for a new, rapid and effective treatment of ocular alkali burns,and a new free radical scavenging agent. Experimental corneal alkali burns in rabbits were treated with highly purified ?_2-maeroglobulin drops extracted from rabbit plasma. On the 1st, 2nd, 3rd, 4th, and 7th day after the burn, examinations of the outer eye were done, On the 2nd, 7th, and 14th day, samples of aqueous humor were drawn to test for theirtotal SOD content. On the 7th and the 14th day the total aqueous protein was also determined. The results showed that on the 1st, 2nd, and 3rd day after the burn, mixed congestion in the experimental group animals was markedly milder than that in the the control group, and on the 2nd and 3rd day, opacity and swelling of the cornea were also less severe in the experimental group. On the 2nd, 7th, and 14th day the tot al aqueous SOD contents of the experimental group were all higher than those of the eontrol samples, but the total aqueous protein which was determined twice showed no statistical significance in the two groups of animals, It was concluded that ?_2-macroglohulin had a marked inhibitory effect on the acute inflammatory reaction of the rabbit corne of alkali burns, and that it also had the power of doing away with superoxide free radieals in the damaged tissue and their metabolites.