Investigation of the role of soluble ICAM-1 and TNF in the acute rejection of renal graft / 中华肾脏病杂志

ABSTRACT

Objective To investigate the role of sICAM-1 and TNF in the acute rejection of renal graft. Methods Serum sICAM-1 and TNF were sequentially determined in 41 patients with renal graft by ELISA and L_(929) target cell methods. Results The change of serum sICAM-1 was same as TNF, there was no significant difference in serum sICAM-1 and TNF among healthy controls, uremic patients, CsA toxioosis and stable transplantation. During acute rejection(AR) and infection episode, both serum sICAM-1 and TNF were obviously elevated. While the serum creatinine had no significant changes during infection, the serum sICAM-1 and TNF were elevated as early as 1～3 days before the rise of serum creatinine. Conclusion The serial assay of serum sICAM-1 and TNF would be helpful in the early diagnosis and differential diagnosis of AR.