~1H-MRS study of brain metabolic disorder in patients with cyanosed congenital heart disease / 中华放射学杂志

ABSTRACT

Objective To study the metabolic alteration in the brain of patients with cyanosed congenital heart disease (CCHD) by using 1H magnetic resonance spectroscopy ( 1H MRS) and discover the pathophysiology of chronic hypoxic brain, which will help to diagnose and treat this disease completely. Methods Twenty five patients with CCHD and 25 controls were performed PRESS 1H MRS and MRI, The areas under the resonance of metabolites were measured, the ratios of the other metabolites to Cr were calculated and compared. Results In patients with CCHD, the mean value of NAA/ Cr was significantly lower than that in controls ( P 0.05). Conclusion 1H MRS can detect brain metabolic changes in patients with cyanosed congenital heart disease in vivo noninvasively and can detect the metabolism disorder of the energy and amino acid, so the pathophysiology of this disease can be understood.