Your browser doesn't support javascript.
loading
THE EFFECTS OF COMPOUND ANTI-TUMOR GRANULES ON GROWTH INHIBITION AND EXPRESSION OF p53 AND PCNA IN MICE BEARING SARCOMA 180 / 解放军医学杂志
Medical Journal of Chinese People's Liberation Army ; (12)2001.
Artigo em Chinês | WPRIM | ID: wpr-552322
ABSTRACT
To study the anti tumor effect of "Compound" granules on mice bearing sarcoma 180 and its possible mechanism, We observed the effect of "Compound" granules on tumor weight and expression of p53 and PCNA in mice bearing sarcoma 180 by means of immunohisto chemistry. After treatment with "Compound" anti tumor granules, anti tumor granules (Ⅰ,Ⅱ,Ⅲ) and CTX, the results showed that "Compound" granules and the other four drugs could inhibit sarcoma 180 growth to various extent, and the rates of inhibition were 20 31%, 6 56%, 15 0%, 19 06% and 30 3%, respectively. Meanwhile,we found the expression of p53 and PCNA in mice bearing sarcoma 180 was affected in various groups.It suggested that compound anti tumor granules had antitumor effect and its possible mechanism might be associated with inhibition the expression of mutate p53 and PCNA.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Medical Journal of Chinese People's Liberation Army Ano de publicação: 2001 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Medical Journal of Chinese People's Liberation Army Ano de publicação: 2001 Tipo de documento: Artigo