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Serum Fluoride Level in Normal Adult Women and Changes in Serum Fluoride Level after Disodium Monofluorophosphate Administration / 대한내분비학회지
Journal of Korean Society of Endocrinology ; : 565-570, 1997.
Artigo em Coreano | WPRIM | ID: wpr-55243
ABSTRACT

BACKGROUND:

Since the morning fluoride level of 10 uM is recommended for adults patients being treated for osteoporosis so far, measurement of serum fluoride level is important to detect abnormally high levels or to detect levels below the therapeutic windows. Aims of this study are to determine the normal range of serum ionic fluoride levels in Korean female adults (from 5th to 7th decade), and to evaluate the in vivo fluoride pharmacokinetics of monofluorophosphate in Korean adults.

METHODS:

Serum level of fluoride was measured from blood samples of 72 female subjects (age 43-69years) using an ion selective electrode. For pharrnacokinetics of monofluorophosphate-calcium (MFP-Ca), 6 subjects (age 27~45 years) were included to be withdrawn the blood hourly for the first S hours and the blood was withdrawn at 24 hours after a single dose of MFP-Ca.

RESULTS:

Mean level of serum fluoride was 1.64+-0.12uM in 5th, 6th, 7th decades adults, and there was no difference of serum fluoride levels among age groups. Peak serum fluoride level exhibited 5.02+-0.67pM, and returned to basal level on 24 hours after a single dose of MFP-Ca.

CONCLUSION:

This study shows that mean serutn fluoride of Korean female adults (from 5th to 7th decade) is not different from that of other reports, and a single dose of MFP-Ca does not cause serum fluoride levels above the recommended therapeutic windows of 5-10uM for 24 hours.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoporose / Valores de Referência / Farmacocinética / Eletrodos / Fluoretos Limite: Adulto / Feminino / Humanos Idioma: Coreano Revista: Journal of Korean Society of Endocrinology Ano de publicação: 1997 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoporose / Valores de Referência / Farmacocinética / Eletrodos / Fluoretos Limite: Adulto / Feminino / Humanos Idioma: Coreano Revista: Journal of Korean Society of Endocrinology Ano de publicação: 1997 Tipo de documento: Artigo