The quantitative analysis of cytomorphology in atypical metaplastic bronchial epithelium / 中国实用内科杂志
Chinese Journal of Practical Internal Medicine
; (12)2001.
Article
em Zh
| WPRIM
| ID: wpr-552527
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the quantitative cytomorphologic parameters in early diagnosis and follow-up of lung cancer.Method With HE staining and image analysis,quantitative analysis of cytomorphology was made on paraffin sections of 86 specimens of bronchial mucosa,sampled by bronchoscopic biopsy,which would reflect a series of events from squamous metaplastic bronchial epithelium to invasive bronchogenic carcinoma.Result 8 nuclear parameters (area,deviation of area,perimeter,deviation of perimeter,shape factor,deviation of shape factor,volume density nucleus,nucleus/plasma ratio)and 2 cellular nodes(perimeter,deviation of perimeter)increased or decreased parallelly with advancing nuclear atypia.Conclusion The two stages of the moderate and severe atypical metaplasia of bronchial epithelium are the critical ones changing from benign to malignant.The quantitative analysis of cytomorphology is useful for discovering and following up the precancerous lesions of bronchogenic squamous cell carcinoma.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Screening_studies
Idioma:
Zh
Revista:
Chinese Journal of Practical Internal Medicine
Ano de publicação:
2001
Tipo de documento:
Article