IN VIVO ~1H NMR SPECTROSCOPY IN RAT C6 GLIOMA / 解放军医学杂志

ABSTRACT

By using the high magnetic field spectrometer to assess the practical value of 1 H NMR spectroscopy in vivo through observation of changes in metabolism of C6 glioma, fourty Wister rats were divided into two groups ten as controls, and in thirty rats C6 glioma cells were implanted spheroids in right caudate nucleus. MR images were carried out at intervals. The 1 H NMR spectroscopy were performed by using point resolved spectroscopy (PRESS) technique. The NAA Cho, Cr+PCr, Glu+Gln, Lip, Lac were observed in normal rats. The NAA intensity was seen to be decreased or disappeared in C6 glioma, and NAA/Cho ratio and NAA/Cr ratio decreased obviously( P