ANALYSIS ON THE RELATIONSHIP BETWEEN PROLIFERATION AND ACTIVATION OF B LYMPHOCYTES AND CD11a, CD54 EXPRESSION IN RENAL ALLOGRAFT RECIPIENTS / 解放军医学杂志

ABSTRACT

To investigate the correlation between activation of B lymphocytes and CD11a, CD54 expression in renal allograft recipients, the dynamic changes in CD19, CD11a and CD54 levels in lymphocytes at different time points were examined by using mAb-FACS-immunofluores-cence technique in 10 renal allograft recipients in stable course(stable group) and 10 with acute rejection(rejection group) after operation. The expression levels of CD19 and CD54 in lymphocytes were significant higher than those of the pre-operation levels in both stable group and rejection group on the 3rd day after kidney transplantation, and the CD19 expression level was significant higher before rejection in the rejection group than that in stable group at the same time points; The expression of CDlla increased from (31. 9 ?12. 4)% to (49. 5 ? 20. 2)% during rejection and decreased significantly after anti-rejection treatment. A negative correlation was found between CD54 and CD19 expression in the stable group(r=0. 7951, P