DIFFERENT EXPRESSION OF MELATONIN RECEPTOR IN HUMAN THYROID NEOPLASM / 解放军医学杂志

ABSTRACT

To investigate the different expression of melatonin receptor between adult thyroid neoplasm and its adjacent normal thyroid tissue, we extracted the total RNA of all kinds of thyroid tissue, synthesized the primer of mt 1, MT 2, and analyzed the mRNA of melatonin receptor by RT-PCR method. mt 1, MT 2 melatonin receptor subtype positive strap expressed in thyroid adenoma as well as in adenocarcinoma. MT 2 in adenocarcinoma had a higher quantity than that in normal thyroid tissue(P0.05). Therefore, mt 1 and MT 2 subtype is present in human thyroid neoplasm tissue, and MT 2 subtype is associated with the occurrence of human adenocarcinoma.