Bone marrow and peripheral blood examination in non-Hodgkin lymphoma at initial diagnosis / 中国实用内科杂志

ABSTRACT

Objective To explore the value of bone marrow and peripheral blood examination in non-Hodgkin lymphoma(NHL) at initial diagnosis.Methods Smears of bone marrow and peripheral blood from 103 cases of NHL were stained according to Wright. Paraffin-embedded sections of bone marrow and lymphadenopathy biopsy were stained according to H-Giemsa-E. Immunotyping of NHL was performed immunohistochemically.Results Bone marrow involvement (BMI) by NHL was found in 28 (27 2%) cases.In 8 of the 28 cases without superficial lymphadenopathy,the diagnosis of NHL was established through bone marrow and peripheral blood examination.Seven of the 28 cases in stage Ⅰ?Ⅱ?Ⅲ were confirmed to be in stage Ⅳ based on bone marrow examination. Lymphoma cells in bone marrow and peripheral blood varied in morphology,they were mainly of four patternsblast type?polymorphic lymphocyte type?small lymphocyte type?histiocyte-like lymphocyte type.Patients with BMI were more likely to have cytopenias in peripheral blood and trilineage of bone marrow depressed than those without BMI.Patients without BMI had a stimulated phenomenon in bone marrow.Conclusion Examination of bone marrow and peripheral blood is important for diagnosis and staging of NHL,especially for the diagnosis of patients without histological evidence of lymph node.