Long-term follow up 104 patients who had been diagnosed by liver tissue immunohistochemical stain assay / 中国实用内科杂志

ABSTRACT

objective To determine the relationship between immunohistochemical stain assay of liver tissue and prognosis of viral hepatitis.Methods 132 patients with chronic hepatitis B diagnosed 6 to 8 years ago by liver biopsy had been followed up by the retrospective and prospective study.The serum hepatitis B virus markers(HBVm)?alpha-fetoprotein(AFP)?Alanine aminotransferase(ALT) and Aspartate aminotransferase(AST)have been detected and B-scan ultrasound of liver and spleen have performed when they stayed at hospital and during follow-up-time,their symptom and physical sign have been recorded simultaneously.Results 4 of 104(3 85%) patients died of cirrhosis;of 100 survival patients,2 patients(2%,2/100) were typical cirrhosis and 16 (16%,16/100) patients were early stage cirrhosis and parenchyma of liver diffuse lesion diagnosed by ultrasound.The serum ALT of patients whose HBcAg and HBsAg were positive in liver tissue was easier fluctuation than those of negative case.Conclusion The status of patients with HBsAg and HBcAg positive in liver tissue is easier fluctuation than those negative,HBsAg and HBcAg positive in liver tissue maybe have no effect on the prognosis of the chronic hepatitis B.