Efficacy evaluation of topiramate in treatment of patients with differe nt types of epilepsy / 中国临床药理学与治疗学

ABSTRACT

AIM: To evaluation the efficacy dosages of topiramate (TMP) in treatment of patients with different types of epilepsy. METHODS: The seizure rate in baseline phase of patients with epilepsy were observed and recorded before treatment of topiramate as monotherapy for 20 weeks. The TMP st arting dosage was 25 mg?d -1 , and then increased to 25 mg?d -1 each week for 8 weeks until effective dosage or 200 mg?d -1 for 12 weeks, and the change of seizure frequency and adverse reactions were recorded. RESULTS: The seizure in 31 cases ( 51.7 %) was totally contro lled, seizure reduction of ≥75% was in 14 cases ( 23.3 %), ≥50% was in 4 cas es ( 6.7 %), and