CD44 and invasion and metastasis of tumors and prognosis of the patients / 中国药理学通报

ABSTRACT

CD44 is a transmembrane receptor protein, belonging to the family of adhesion molecules, which is involved in cell-cell and cell-matrix interactions by binding with ligands such as hyaluronan. Recently a lot of researches reported that CD44 and its variant isoforms, especially CD44v6, are usually aberrantly expressed in many kinds of tumor cells, which is correlated with the invasion and metastasis of tumors and the prognosis of the patients.