PPARs:Target for lipid metabolism disorder and insulin resistance therapy / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Artigo
em Chinês
| WPRIM
| ID: wpr-554840
ABSTRACT
The peroxisome prolifrator-activated receptors(PPARs)? and ? constitute a subfamily of nuclear receptors. PPAR? has been shown to be activat ed by the hypolipidemic drugs of the fibrate class; While the antidiabetic TZD a re synthetic ligands for PPAR?. Upon binding and activation by their ligands, t hey regulate the transcription of numerous genes involving lipid metabolism and insulin resistance. The research indicated that PPAR? also plays a key role in lipid metabolism. PPARs therefore constitute interesting targets for the develop ment of single and dual agonists useful in the treatment of obesity and type 2 d iabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Artigo
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