Research on relationship between interleukin-1 receptor antagonist and airway hyperresponsiveness / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-555222
ABSTRACT
AIM:
To explore the relationship between interleukin-1receptor antagonist (IL-1ra) and airway hyperresponsiveness (AHR) of asthma.METHODS:
The airway responsiveness to inhaled histamine as PC 20 was evaluated among the normal guinea pigs, and sensitized with ovalbumine (OA) and challenged 14 days later (athma group), and injected IL-lra 1 mg?kg -1 intravenously 30 minutes before challenged (asthma plus IL-lra group). The numbers of different cells was counted and classified in bronchoalveolar lavage fluid (BALF).RESULTS:
The PC 20 of the asthma plus IL-1ra group was higher than that of asthma group (P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2004
Tipo de documento:
Artigo
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