Cyclosporin A exerts neuroprotective effects after diffuse axonal injury in the rat / 解放军医学杂志

ABSTRACT

Objective To determine whether cyclosporin A(CsA) could exert neuroprotective effects after diffuse axonal injury (DAI) in the rat. Methods Twenty four SD rats were randomly assigned into three groups non injur group ( n =8); control brain injury group ( n =8), in which normal saline was given; and experimental group ( n =8), the injured rats were treated with CsA. The beam balance test device and Morris water maze were used to test for balance and cognitive performance. Results Control brain injury animals displayed severe defects in balance and cognitive performande after diffuse axonal injury. Compared with control brain injury animals, rats treated with CsA displayed better motor performance in beam balance tests and improved learning ability in the Morris water maze. Conclusions It is demonstrated that CsA exhibits substantial neuroprotective activity in a rat model of DAI. These findings support that CsA is a useful therapeutic agent in the treatment of DAI.