Acamprosate-induced Extrapyramidal Symptoms in an Elderly Patient with Alcohol Dependence
Clinical Psychopharmacology and Neuroscience
;
: 166-168, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-55541
ABSTRACT
Acamprosate reduces the craving for alcohol by decreasing glutamate activity and increasing gamma-aminobutyric acid (GABA) action in patients with alcohol dependence. Acamprosate has tolerable side effects that include diarrhea, headache, dizziness and pruritus. In this study, we report acamprosate-induced extrapyramidal symptoms in an elderly patient with no history of neurologic disease. Severe extrapyramidal symptoms developed two days after the administration of acamprosate and improved over one week after the acamprosate was stopped. Extrapyramidal symptoms are commonly associated with dopamine receptor antagonists. However, there have been several reports of extrapyramidal symptoms occurring with drugs targeting other systems, including GABA, glutamate and serotonin. Acamprosate may decrease dopamine levels in the ventral tegmental area mediated by glutamatergic action and thus cause extrapyramidal symptoms. We suggest that acamprosate carries the risk of causing extrapyramidal symptoms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prurido
/
Dopamina
/
Serotonina
/
Área Tegmentar Ventral
/
Ácido Glutâmico
/
Antagonistas de Dopamina
/
Diarreia
/
Tontura
/
Alcoolismo
/
Ácido gama-Aminobutírico
Tipo de estudo:
Estudo diagnóstico
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2014
Tipo de documento:
Artigo
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