Study on the changes in cholinergic nerves and nitrergic nerves in colonic myenteric plexus in rats with slow transit constipation / 解放军医学杂志

ABSTRACT

s Objective To study the changes in cholinergic nerves and nitrergic nerves in colonic myenteric plexus in rats with slow transit constipation. Methods Slow transit constipation model of rat was reproduced by feeding Diphenoxylate. The changes in cholinergic nerves and nitrergic nerves in colonic myenteric plexus were studied by histochemical technology. Results In the rats with slow transit constipation, the numbers of nitriergic cells and cholinergic cells in the myenteric nerves were significantly decreased compared with control group. The volume of neuron in AchE ganglia was larger than that of control. Conclusion Dysfunction of colon transit was related with the changes in cholinergic nerves and nitrergic nerves of colonic myenteric nerve plexus in rats with slow transit constipation.