Progress in the research of P-gp inhibitors / 中国临床药理学与治疗学

ABSTRACT

Multidrug resistance (MDR) is one of the major obstacles to cancer chemotherapy. It is now well established that MDR phenotype is strongly correlated with the over expression of P glycoprotein (P gp), a membrane glycoprotein encoded by MDR1 gene. There is very great progress in the research of the P gp inhibitors in recent years. This article describes the current research state of the P gp inhibitors.