Relationship between nitration and oxidation related enzymes iNOS,COX-2 and hematological malignancies / 第二军医大学学报

ABSTRACT

Inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) are nitration and oxidation related enzymes, and their correlations with tumors have been drawing more and more attention.There are 2 different viewpoints on the correlation between the 2 enzymes and hematological malignances,and their functioning mechanisms are still unclear.The selective inhibitors of NOS,COX,or the both may provide a new approach for the treatment of hematological malignancies.