The influence of p14~ (ARF) and p16~(INK4a) protein co-expression status on radiochemotherapy and survival rate of patients with non-small cell lung cancer after resection / 解放军医学杂志

ABSTRACT

Objective To investigate the influence of co-expression state of p14 ARF and p16 INK4a protein on radiochemotherapy and length of survival period in patients with non-small cell lung cancer(NSCLC)after resection. Methods Thirty-five patients with negative p14 ARF and p16 INK4a co-expression and 20 patients with positive p14 ARF and p16 INK4a co-expression were enrolled for the study. The co-expression of the said proteins were previously determined by immunohistochemistry (S-P). Clinical pathological characteristics were compared between two groups, and the survival time and the results of radiochemotherapy of patients were respectively recorded and analysed. Results No significant differences were found in age, TNM stages, degree of differentiation, recurrence/metastasis and radiochemotherapy between two groups. However, there was significant differences in sex, smoking index, and pathological classification. It was found that 2-year, 3-year and total survival rate were significantly lower in patients with p14 ARF and p16 INK4a co-expression than those with positive co-expression (P