Effect of PKC antagonist-chelerythrine on mouse pancreatic secretion stimulated by cholecystokinin / 中国实用内科杂志
Chinese Journal of Practical Internal Medicine
;
(12)2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-555914
ABSTRACT
Objective To establish a mouse pancreatic exocrine secretion system,in order to study the effect of secretagogues,such as cholecystokinin (CCK) and carbachol (CCH),on the exocrine secretion of mouse pancreas,and use a protein kinase C (PKC) antagonist-chelerythrine(Che) to research the possible mechanism.Methods Prospective control study.Results CCK and CCH increased the secretion of amylase from the mouse pancreatic acini about two fold of that of the control (7.02%vs14.29%),and,CCK or CCH added Che,could increase the secretion of amylase to a level of about three fold(19.02%).Conclusion CCK or CCH stimulate the pancreatic secretion concerning the PKC cellular signal system;surprisingly,a PKC antagonist,chelerythrine,can reinforces their stimulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Practical Internal Medicine
Ano de publicação:
2003
Tipo de documento:
Artigo
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