EFFECT OF SOYASAPONINS IN PREVENTION OF HYPERLIPIDEMIA IN MICE AND ITS MOLECULAR MECHANISM / 营养学报
Acta Nutrimenta Sinica
;
(6)1956.
Artigo
em Chinês
| WPRIM
| ID: wpr-556378
ABSTRACT
Objective:
To investigate effect of soyasaponins in the prevention of hyperlipidemia in mice and its molecular mechanism.Methods:
56 healthy mice were randomly divided into 7 groups according to their levels of TC in serum normal control, high fat control, high fat with 20mg/kg.d gypenosides,high fat with soyasaponins of four doses(5 mg/kg.d, 10mg/kg.d, 20mg/kg.d, 30 mg/kg.d).Results:
As compared to high fat control soyasaponins significantly reduced the serum TC, LDL-C, TG concentrations, and increased the HDL-C levels distinctly. They significantly deceased MDA content, increased the activities of SOD and LPL in liver. The results of RT-PCR showed that high fat feeding could induce the reduction of LPL mRNA expression, while soyasaponins could increase it.Conclusion:
Soyasoponins prevent hyperlipidemia through upregulation of LPL mRNA expression and increase of antioxidative capacity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Nutrimenta Sinica
Ano de publicação:
1956
Tipo de documento:
Artigo
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