Immunomdulatory effects of total flavones of oldenlandia diffusa willd / 中国药理学通报

ABSTRACT

Aim To investigate the immunomdulatory effects of total flavones of oldenlandia diffusa willd (FOD).Methods In immunosuppressed mice induced by cyclophosphamide, IgM production,proliferation of T and B lymphocytes, levels of IL-2 and INF-? in serum were used to study the specific immunity of FOD. White blood cell count of mice suppressed by cyclophosphamide and cytarabine was used to observe the non-specific immunity of FOD.Results FOD(60 (mg?kg~(-1))) enhanced IgM production in (immunosup-)pressed mice induced by Cy and white blood cell count of mice suppressed by cytarabine and cyclophosphamide ;FOD(15,30 and 60 mg?kg~(-1)) increased proliferation of T and B lymphocytes and enhanced levels of IL-2 and INF-? in serum in immunosuppressed mice induced by cyclophosphamide. Conclusion FOD enhances the specific and non-specific immunity.