Your browser doesn't support javascript.
loading
Protective effect of rosiglitazone on cyclosporine A-induced nephrotoxicity in rat NRK cells / 中华肾脏病杂志
Chinese Journal of Nephrology ; (12)1997.
Artigo em Chinês | WPRIM | ID: wpr-556582
ABSTRACT
Objective To investigate the protective effects of rosiglitazone (RSG) on normal rat kidney cells (NRK) damaged by cyclosporine A(CsA). Methods The NRK cells were cultured with CsA or with CsA plus rosiglitazone. The cellular proliferation was determined by MTT colorimetry. The mRNA expression of TGF-?1 and PPAR? was detected by RT-RCR. Protein levels of PPAR?, p-ERK,FN and AT1R were examined by Western blotting. The level of TGF-?1 in the supernatants was measured by enzyme-linked immunosorbant assay (ELISA). Results CsA inhibited the proliferation of NRK cells in dose and time dependent manner (P

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Nephrology Ano de publicação: 1997 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Nephrology Ano de publicação: 1997 Tipo de documento: Artigo