GPCR-G? fusion protein and its applications on ligand screening of orphan G protein-coupled receptors / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Artigo
em Chinês
| WPRIM
| ID: wpr-556612
ABSTRACT
GPCR-G alpha fusion protein has been used to investig ate receptors in recent years. The expression of GPCR-G alpha fusion protein en sured defined 1∶1 stoichiometry, the physical proximity of GPCR to G alpha subu nit, and was suitable for high-throughput ligand screening. The fusion protein technology provided a novel strategy to study orphan GPCRs. Obviously, it will p lay important roles in ligand screening of the orphan GPCRs and exert its signif icances in the R&D of novel drugs targeted at oGPCRs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1986
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS