Interleukin-6 is involved in the enhanced proliferation of HEK293 cells by the tumor specific antigen of HCA520 / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6)2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-556701
ABSTRACT
Objective:
To investigate the effect of tumor specific antigen of HCA520 on the proliferation of HEK293 cells and to obtain some functional implications for HCA520.Methods:
MTT assay was performed with HEK293 stable cell lines transfected with pcDNA3-HCA520-flag construct. Cytokines probably involved in HCA520 enhanced proliferation were screened by RT-PCR, and effect of these cytokines on the HEK293 cell proliferation was further confirmed by MTT assay.Results:
HCA520 significantly promoted the proliferation of HEK293 cells, which was at least partially attributed to the up-regulation of IL-6 in HEK293 cells by HCA520.Conclusion:
HCA520 might accelerate tumorigenesis by promoting proliferation of cancerous cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Peking University(Health Sciences)
Ano de publicação:
2004
Tipo de documento:
Artigo
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