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Antitumor effects of novel thymidylate synthase inhibitor ZD1694 in vitro and in vivo / 中国临床药理学与治疗学
Article em Zh | WPRIM | ID: wpr-556743
Biblioteca responsável: WPRO
ABSTRACT
10 mg?kg -1?d -1? 5 d. The inhibitory rate of ZD1694( 0.001- 1 000 mmol?L -1)on SGC-7901 cells were increased in concentration and time-dependent manner. The cell numbers in G_0-G_1 phase in SGC-7901 cells were raised by ZD1694 as well. CONCLUSION: ZD1694 can take obvious antitumor effects on S180-bearing mice. The antitumor rate of ZD1694 is in a dose-dependent manner, and it is higher when the total dosage is administered in one day than that the total dosage was divided into 5 consecutive days. ZD1694 can inhibit the growth of SGC-7901 cells and block the cells in G_1 phase in vitro.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Clinical Pharmacology and Therapeutics Ano de publicação: 2002 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Journal of Clinical Pharmacology and Therapeutics Ano de publicação: 2002 Tipo de documento: Article