Tumor necrosis factor-related apoptosis-inducing ligand and tumor immunity / 中国药理学通报

ABSTRACT

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily.It is extensively expressed on different tissues and cells. TRAIL can initiate singnaling through binding to TRAIL receptors. TRAIL selectively induces apoptosis of a variety of tumor cells, but has less toxition or no damage to most normal cells. TRAIL treatment in combination with chemotherapy drugs and cytokines can induces apoptosis of tumor cells. But a tumor emerges immune escape or immune privilege by expressing TRAIL on itself. The action of TRAIL is influenced by NF-?B or type and amount of TRAIL receptors on target cell.