Advances in the pathogenesis of shock / 解放军医学杂志

ABSTRACT

Irreversible shock is one of the major target in shock research. The dysfunction of mitochondria involves in the pathogenesis of shock and MODS. Capillary no-reflow post-treatment leads to decrease of functional capillary density (FCD), which is a predictor of bad prognosis. Refractory hypotension after treatment results in low perfusion of vital organ, which is also one of the causes for death. Hypovisosaemia is a problem in shock treatment with massive fluid infusion leading to the decrease of FCD and survival rate. The mechanisms of the issues mentioned above are discussed in the text.