Evaluation of therapeutic effects with intra-operative iodine-125 seed implantation for advanced pancreatic carcinoma / 中华放射肿瘤学杂志

ABSTRACT

Objective To analyze the clinical effects of internal radiation of iodine-125 seed implantation in the treatment of advanced pancreatic carcinoma.Methods Ten patients with unresectable and advanced pancreatic carcinoma admitted from Sept.2002 to June 2004 were treated by the internal and interstitial radiation using iodine-125 seed implantation. Sexmale 6, female 4. Age median 60.8(45-81) years. Site by pre-operative CT pancreatic head 4, body 2 and tail 4. Diameter 6?cm 3. Pathology all proved to be pancreatic adenocarcinoma. Staging(UICC 1997) stage Ⅲ 3, IV 7. Pain degree Ⅲ 3,IV 7. Weight loss median 5?kg(3-10?kg). Results All patients have been followed for 2-13 months, median 6 months. Survival of 12 months was observed in 1 patient,6 months in 3 patients, 3 months in 4 and 1 month in 2, with an average of 4.6 months. Among the 10 patients, complete response was obtained in 2, partial response in 3, no response in 4, and the other showing PD. The response rate (CR+PR) was 50%. The pain relieving rate was 60%. The seed number conformal rate was 100% by X-ray film, yet that of seed spatial distribution was only 30%. Conclusion Intra-operative internal radiation by iodine-125 seed implantation does show some therapeutic effects for advanced pancreatic carcinoma.Yet,the seed spatial distribution by seed computer treatment planning system does needs further consummate.