Inhibition effects of methylprednisolone on over-expression of transforming growth factor-?_1(TGF-?_1) in kidneys of BXSB mice / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-556919
ABSTRACT
AIM:
To investigate the relationship between TGF-?_1 over-expression and lupus nephritis(LN) in BXSB mice and whether MPS ameliorates LN by inhibiting the over-expression of TGF-?_1.METHODS:
BXSB mice (experiment group, n=6) were treated (i.p.) with MPS (25 (mg?kg~(-1)?d~(-1))) dissolved in N.S for 3 weeks. The other age and sex-matched BXSB mice (n=6) and BALB/c mice (n=6) received N.S. alone. Proteinuria production was evaluated once a week. The expression of TGF-?_1 in the kidney was investigated by means of immunohistochemistry and RT-PCR.RESULTS:
MPS significantly reduced proteinuria of BXSB mice (P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS