Changes of propofol blood concentrations in rats during anhepatic phase by continuous constant-speed infusion of propofol / 第三军医大学学报

ABSTRACT

Objective To observe the changes of propofol blood concentrations in rats during anhepatic phase by continuous constant-speed infusion of propofol and to investigate the extrahepatic metabolism of propofol and the effects of lungs on the extrahepatic metabolism of propofol. Methods When the continuous constant-speed transfusion of propofol was carrying out through the left deep cervical vein, the blood samples of 100 ?l were withdrawn simultaneously from the right deep cervical artery and vein at the flowing time points 5 min before the dissociation of hepatic portal, immediate devascularization of the hepatic portal, 15 min, 30 min and 60 min after devascularization of the hepatic portal. The propofol blood concentrations were analyzed by HPLC. Results At 15 min, 30 min and 60 min after the devascularization of the hepatic portal, the propofol blood concentrations in the right deep cervical artery and vein were significantly higher than that at 5 min before the dissociation of hepatic portal and immediate devascularization of the hepatic portal (P