The effect of Bay k8644 on cardiac function of myocardial ischemia-reperfusion injury in rats / 中国药理学通报

ABSTRACT

Aim To study the effect of Bay k8644 on cardiac function with the model of myocardial ischemia-reperfusion injury(MIRI)in Rats.Methods Rat MIRI was induced by occluding the left anterior descending coronary artery for 40 min followed by 90 min reperfusion.Eighteen rats were divided randomly into 3 groups saline,Bay k8644 and 0.1% dimethyl sulfoxide(DMSO)intravenously injected 30 min after ischemia.Heart functions were assessed before ischemia and 5,20 and 40 min after initiation of ischemia and 5,30,60 and 90 min after reperfusion,by measuring heart rate(HR),the left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP) and ?dp/dt_(max).Results After ischemia,LVSP and +dp/dt_(max) decreased(P