Effects of Panax Notoginseng Saponins on expression of Caspase after focal cerebral ischemia-reperfusion in rats / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Artigo
em Chinês
| WPRIM
| ID: wpr-558157
ABSTRACT
Aim To investigate the effects of Panax Notoginseng Saponins(PNS) on expressions of Caspase-1,Caspase-3 and Caspase-8 after transient focal cerebral ischemia-reperfusion(CIR).Methods CIR injury was induced by middle cerebral artery occlusion(MCAO) in rats.The rats were treated with PNS(25 mg?kg~(-1)) and Nimodipine(1 mg?kg~(-1)).The drugs were administered 5 min before cerebral ischemia,and 12,24 and 36 h after cerebral ischemia.Sham operation group and model group were givenequal volume normal saline.The expressions of Caspase were observed by using immunochemistry after cerebral ischemia for 2 h followed by reperfusion for 46 hours.Results The expressions of Caspase-1 and Caspase-3 protein increased after cerebral ischemia.PNS decreased the expressions of Caspase-1(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Artigo
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