Function of apoptosis induced by derivatives of retinoid acid on tumor cells / 中国药理学通报

ABSTRACT

Retinoid acid and its derivatives have shown promising perspective in clinical use and lab research on the leukemia and other solid tumor cells.Some of these compounds have a stronger apoptotic potential,a lower level of cytotoxicity and a better pharmacokinetic profile than all-trans retinoic acid.The apoptosis pathways induced by these compounds are different from traditional p53-dependent pathway which recruited by many chemotherapeutics.Due to its specific molecular mechanism,these compounds could induce apoptosis in retinoic acid-resistant or multi-drug-resistant tumor cells.This paper reviews the current research on apoptosis induced by analogues of retinoid acid.