P-Glycoprotein and Blood-Brain Barrier / 国际脑血管病杂志
Article
em Zh
| WPRIM
| ID: wpr-558586
Biblioteca responsável:
WPRO
ABSTRACT
P-glycoprotein is one of the members in the superfamily of ATP-binding cassette transporters. It is expressed in many sites in vivo, and is correlated with multidrug resistance. Under physiological conditions, as an efflux pump, P-glycoprotein in the blood-brain barrier can eliminate endogenous substrates and xenobiotics to maintain the balance of internal environment. But at the same time, it also limits the concentration of therapeutic drugs in brain, and thus reduces therapeutic efficacy. P-glycoprotein inhibitors can get drugs across the blood-brain barrier. It is of great importance to improve the blood concentration in brain and bioavailability of central nervous system drugs.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
International Journal of Cerebrovascular Diseases
Ano de publicação:
2006
Tipo de documento:
Article