Advances in bioreactors for cartilage tissue engineering / 国际生物医学工程杂志

ABSTRACT

In vitro construction technology is a key approach to industrialization and clinic application of engineered cartilage. However, it is very difficult to acquire a functional engineered cartilage with the present technology. Bioreactors can simulate the cartilage microenvironment in vivo and are expected to make up the shortcoming of the present technology. Current bioreactors in use are designed according to fluid shear pressure, hydrostatic pressure and/or direct compression, all of which can promote the development and mature of cartilage in vivo. Due to the failure to achieve ideal results by a single-purpose bioreactor, it will become a development direction in future to design and produce a compound bioreactor. This article reviewed the advances in the bioreactor for cartilage tissue engineering.