Relation between fasting C-peptide and insulin resistance / 中国实用内科杂志

ABSTRACT

Objective To compare the differences between C-peptide and insulin in evaluation of insulin resistance.Methods From 2003 to 2004,according to oral 75 g glucose tolerance test(OGTT),44 subjects were divided into normal glucose tolerance(NGT)group,isolated impaired fasting glucose(I-IFG)group,isolated impaired glucose tolerance(I-IGT)group and combined impaired glucose tolerance(C-IGT)group.We discussed the relationship between glucose infusion rate(GIR)by hyperinsulin euglycemic clamp and IAI,HOMA-IR,QUICKI(these indexes from fasting insulin level),fasting C-peptide level,respectively.Results (1)GIR of I-IFG,I-IGT,C-IGT groups declined significantly compared with that of NGT group(P0.05).IAI,HOMA-IR and QUICKI of each group were of good relation to GIR respectively(P0.05),whose relative rates were among 0.394~0.042.Conclusion The level of fasting C-peptide has no relationship wiht the degree of insulin resistance.