The protective and therapeutic effects of total flavonoids of litsea coreana level on nonalcoholic steatohepatitis in rats / 中国药理学通报

ABSTRACT

Aim To study the preventive and therapeutic effects of total flavonoids of Litsea Coreana level on nonalcoholic steatohepatitis in rats.Methods 48 SD rats were randomized into control,model,NA,TFLC(50,100,200 mg?kg~(-1))groups(n=8).The control group were only fed with a standard diet and the other groups were fed with a standard diet and fat emulsion(10 ml?kg~(-1));At the same time,the control and model groups were fed with CMC-Na,the other groups were fed with relative medicine.The stool TG,TC,the serum TG,TC,ALT,AST,MDA,SOD and hepatic TG,TC,MDA,SOD were detected dynamically.Results The model group developed NASH after 3 weeks.NA and TFLC(100,200 mg?kg~(-1))significantly reduced TG of the serum and liver tissue,and ameliorated hepatocellular macrovesicular steatosis.TFLC(200 mg?kg~(-1))markedly inhibited increased MDA in serum and liver tissue,and also elevated SOD in liver tissue.Conclusions TFLC markedly reduced the TG level of serum and liver tissue.Liver histopathological examination showed TFLC ameliorated hepatocellular macrovesicular steatosis.The protective and therapeutic effects of TFLC on NASH may be associated with inhibitory effect of fat absorption and lipid peroxidation.