Effects of ketamine on expression of nitric oxide synthase in medial septal nuclei and vertical diagonal band of rats / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-558953
ABSTRACT
AIM:
To explore the effects in different dosage of ketamine on the expression of nitric oxide synthase (NOS) in medial septal nuclei (MS) and vertical diagonal band (VDB) of rats.METHODS:
40 SD rats were randomized into normal control group,normal saline(NS) group, low, middle and high dosage of ketamine(25,50,100 mg?kg~ -1 ,ip) group.Each group was maintained intraperitoneally by given daily dosage once a day for a period up to 7 days. That was done at 2100 hour each night, and by 2 h of the last administration, poured, fixed and sliced were carried out. Method of nicotinamide adenosine dinucleotide phosphate diaphorase (NADPH-d) was used to show the expression of NOS in MS and VDB pars dorsalis and ventro.RESULTS:
Compared with normal control and NS group, the number of NOS positive neurons were decreased in MS and VDB pars dorsalis and ventro in ketamine groups.There were statistical meaing in different-dosage groups of ketamine(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2002
Tipo de documento:
Artigo
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