Induction of Apoptosis with Moringa oleifera Fruits in HCT116 Human Colon Cancer Cells Via Intrinsic Pathway
Natural Product Sciences
;
: 227-234, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-55957
ABSTRACT
Moringa oleifera Lam (M. oleifera, Moringaceae) is a tree of the Moringaceae family that can reach a height of between 5 and 10 m. The current paper presents cytotoxic effect of M. oleifera fruits and its flavonoids 1 and 2. The viability of HCT116 human colon cancer cells were 38.5% reduced by 150 µg/mL of ethanolic extracts in a concentration-dependent manner; in addition, we observed the apoptotic features of cell shrinkage and decreased cell size. Bcl-2 family proteins were regulated as determined by Western blotting analysis, suggesting that M. oleifera fruits and their flavonoids 1 and 2 induced apoptosis through an intrinsic pathway. Based on our findings, 70% ethanolic extracts of M. oleifera fruits and flavonoids 1 and 2 might be useful as cytotoxic agents in colorectal cancer therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Árvores
/
Flavonoides
/
Neoplasias Colorretais
/
Western Blotting
/
Apoptose
/
Colo
/
Neoplasias do Colo
/
Moringa
/
Moringa oleifera
/
Citotoxinas
Limite:
Humanos
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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